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Can My Dog Take Galliprant And Gabapentin Together?



Reviewed By: Dr. Joel Robertson

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When it comes to managing pain and inflammation in dogs, veterinarians often prescribe medications such as Galliprant and Gabapentin.

However, many pet owners may wonder if it’s safe for their dogs to take both medications simultaneously.

In this article, we will delve into the uses and potential interactions of Galliprant and Gabapentin, as well as explore the benefits and precautions of administering these medications together under the guidance of a veterinarian.

What Is The Difference Between Galliprant And Gabapentin?

Can My Dog Take Galliprant And Gabapentin Together

Galliprant and gabapentin are two common medications used for different purposes in veterinary medicine.

Galliprant is a nonsteroidal anti-inflammatory drug (NSAID) that is typically prescribed to alleviate pain and inflammation in dogs with osteoarthritis.

On the other hand, gabapentin is an anticonvulsant and neuropathic pain medication that can be used to manage chronic pain, anxiety, and epilepsy in dogs.

One significant difference between the two drugs is that galliprant blocks the action of COX-2 enzymes that are responsible for inflammation, while gabapentin works by blocking the activity of certain neurotransmitters that cause nerve pain.

Moreover, galliprant is a newer drug than gabapentin and has been approved by the FDA specifically for use in dogs, while gabapentin is a human drug that is prescribed “off-label” for dogs.

This means that while gabapentin can be used for dogs, it has not undergone the same rigorous testing and approval process by the FDA.

Veterinary professionals should evaluate the individual case and medical history of each dog to determine which medication may be the most suitable course of treatment.

Can My Dog Take Galliprant And Gabapentin Together?

Yes. It is possible for a dog to take Galliprant and Gabapentin together, but it is important to consult with a veterinarian before administering any medication.

Galliprant is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation associated with osteoarthritis in dogs.

On the other hand, Gabapentin is a medication used to manage seizures, chronic pain, and anxiety in dogs. Since both medications have different modes of action, they can be prescribed together for dogs with multiple conditions.

However, it is important to note that both medications have potential side effects. Galliprant can cause digestive issues, such as vomiting and diarrhea, and may also lead to liver and kidney problems.

Gabapentin can cause dizziness, drowsiness, and loss of coordination in dogs. Therefore, taking both medications together may increase the likelihood of experiencing these side effects.

Before prescribing any medication, a veterinarian will conduct a thorough health assessment of the dog and may recommend other courses of treatment.

It is also crucial to follow the dosage instructions carefully and report any adverse reactions to the veterinarian immediately.

What Is Galliprant?

Galliprant is a type of medication that belongs to the class of drugs known as Nonsteroidal anti-inflammatory drugs (NSAIDs).

It is primarily used in veterinary medicine to treat pain and inflammation caused by osteoarthritis in dogs. The active ingredient in Galliprant is grapiprant, which works by blocking a specific receptor in the dog’s body, known as the EP4 receptor.

This receptor is responsible for causing inflammation and pain in dogs with osteoarthritis. By blocking this receptor, Galliprant can reduce pain and inflammation without causing unwanted side effects often associated with other NSAIDs, such as stomach ulcers, kidney damage, or liver damage.

Galliprant is a prescription medication, and it is usually administered as a pill or chewable tablet. It is safe and effective for dogs of various breeds and sizes. But, it should only be used under the supervision of a veterinarian.

As with any medication, it is important to follow the prescribed dosage and to watch for any potential side effects. Overall, Galliprant offers a valuable treatment option for dogs with osteoarthritis. It helps to improve their mobility, comfort, and quality of life.

What Is Gabapentin?

Gabapentin is an anticonvulsant drug that is primarily used to treat seizures and neuropathic pain. It was initially approved by the U.S. Food and Drug Administration in 1993.

However, its use has expanded to include the treatment of other medical conditions such as restless leg syndrome, hot flashes, anxiety disorders, and bipolar disorder.

The drug acts by binding to certain neurotransmitters in the brain and reducing their activity, which in turn reduces the excitation of nerve cells.

This, in turn, helps to reduce nerve pain and seizures. Gabapentin is available in different forms including capsules, tablets, and oral solution.

Its dosage varies depending on the condition being treated and the patient’s age and weight. However, the starting dose for adults is usually between 300mg and 600mg, taken orally three times a day.

Like any other medication, Gabapentin has some side effects such as dizziness, drowsiness, and nausea. It is essential to consult a healthcare provider before using the medication to ensure that it is safe and suitable for use.

Also, patients should not abruptly stop taking Gabapentin as it may cause withdrawal symptoms and seizures. It is advisable to adjust the dosage gradually.

Is Gabapentin or Galliprant Better At Treating Arthritis Pain For Dogs?

When it comes to which medication is better at treating arthritis pain for dogs, it really depends on the individual dog and the severity of their arthritis.

For some dogs, gabapentin may be more effective in reducing their pain as it directly targets nerve pain.

For others, Galliprant may be more effective in reducing inflammation and therefore reducing pain. It is important to consult with a veterinarian to determine the best treatment plan for your dog’s specific needs and to ensure that any medication prescribed is safe and appropriate for your dog.

Both medications have potential side effects, so it is important to closely monitor your dog and report any changes or concerns to your veterinarian.

What Can I Give My Dog Instead of Galliprant?

If your dog requires pain relief and you are unable to give them Galliprant, there are a few alternatives that you could consider.

One option is to use fish oil supplements, which have been shown to have anti-inflammatory properties and can reduce joint pain in dogs.

Another alternative is to use glucosamine and chondroitin supplements, both of which can help to support joint health and reduce inflammation.

Additionally, CBD products are becoming increasingly popular as pain relief for dogs, however, it is important to do your research and ensure that you are purchasing a high-quality, trustworthy product.

Alternatively, traditional painkillers such as acetaminophen or aspirin could be used, although it is important to follow the dosage instructions carefully and to consult with your veterinarian beforehand.

What is an Alternative To Gabapentin For Dogs?

One alternative is Pregabalin, a medication that works similarly to Gabapentin. It helps calm down the over-excited nerves which cause pain and seizures.

Another alternative is Tramadol, which is a pain medication that works by blocking the pain signals from reaching the brain.

It is essential to consult a veterinarian to determine the most appropriate treatment plan for your furry friend.

They will assess the dog’s medical history and conditions to suggest the best medication and dosage.

Additionally, alternative treatments such as physical therapy, acupuncture, and herbal supplements may also be helpful in managing pain and improving the dog’s quality of life.

It is essential to have regular check-ups with the veterinarian to ensure your dog is healthy and comfortable.

Does Gabapentin Help Dogs With Arthritis?

This drug works by affecting neurotransmitters in the brain, leading to the relief of pain and discomfort caused by arthritis.

There is no official approval by the FDA for the use of gabapentin in dogs. So, many veterinarians prescribe the medication for off-label use.

Gabapentin has been found to be effective in managing chronic pain in dogs, including that caused by arthritis.

However, it is essential to note that gabapentin is not a cure for arthritis, and it only gives temporary relief to the symptoms.

It is also advisable to administer the medication under the guidance and recommendation of a licensed veterinarian.

Is Gabapentin Safe For Dogs?

While gabapentin is generally considered safe for dogs, there are some potential side effects that pet owners should be aware of.

Common side effects may include drowsiness, dizziness, and loss of coordination. In some cases, dogs may also experience diarrhea, vomiting, or changes in appetite.

More serious side effects are rare, but they may include seizures, difficulty breathing, or an allergic reaction.

It is important to follow your veterinarian’s instructions carefully when administering gabapentin to your dog and to monitor your pet for any signs of side effects.

The dosage of gabapentin may need to be adjusted based on the dog’s weight and medical history.

Overall, gabapentin can be a safe and effective treatment option for dogs with certain medical conditions. It should only be used under the guidance of a veterinarian.

What is The Best Pain Medication For Dogs With Arthritis?

There are several pain medications that can help alleviate arthritis pain in dogs, such as non-steroidal anti-inflammatory drugs (NSAIDs), opioids, and disease-modifying osteoarthritis drugs (DMOADs).

NSAIDs are often the first choice in treating arthritis pain, providing both pain relief and reducing inflammation.

Some common NSAIDs for dogs include carprofen, meloxicam, and deracoxib.

Opioids, such as tramadol and codeine, are used for more severe pain or when NSAIDs are not effective. DMOADs, like Adequan and Cartrophen, are injectable medications that help restore joint function and protect cartilage.

The best pain medication for dogs with arthritis depends on each individual case, the severity of the condition, and the dog’s health status.

What is The Dose of Gabapentin For Dogs?

Generally, veterinary professionals recommend starting with a low dose and gradually increasing it until the desired effect is achieved without causing any side effects.

For most dogs, the initial dose may range from 1.5 to 5 mg per pound of body weight, given two to three times daily.

However, in some cases, such as when the dog is suffering from severe pain, the veterinarian may prescribe a higher dose, up to 10mg/lb or more.

It’s essential to follow the dosage guidelines provided by the veterinarian carefully. Don’t adjust the dosage without their advice.

Overdose or abrupt withdrawal of gabapentin can have adverse health effects on dogs, such as seizures, tremors, and other neurological problems.

Therefore, it’s crucial to monitor the dog’s response to gabapentin carefully. Seek veterinary help immediately if there are any changes in their behavior or health.

How Long Will Gabapentin Stay in My Dog’s System?

On average, gabapentin can stay in your dog’s system for approximately 48-72 hours since the last dose. However, it is not uncommon for it to take up to 4-5 days to be completely eliminated.

The liver also plays a role in gabapentin metabolism, so dogs with liver problems may experience a prolonged elimination time.

Therefore, it is important to follow your veterinarian’s instructions and only administer gabapentin as directed.

In case you have concerns about potential adverse side effects or interactions with other medications, always consult with your vet to get more information and make sure your dog is safe and healthy.

Are There Situations Where Gabapentin Could Hurt My Dog?

There are circumstances under which gabapentin could hurt your dog. Some dogs may be allergic to gabapentin and could experience severe reactions.

It is also important to avoid giving gabapentin to any dog that has a history of liver or kidney disease or that is currently taking other medications that could interact with gabapentin.

Always consult with your veterinarian before administering any medications to your dog.

Gabapentin VS Galliprant Side Effects

It’s important to be aware of the potential side effects of both medications when they are administered to your dog.

Gabapentin Side Effects:

  1. Drowsiness or sedation: Gabapentin may cause some dogs to become drowsy or sleepy. This is usually mild and may lessen over time as the dog’s body adjusts to the medication.
  2. Loss of coordination: Some dogs might experience a lack of coordination or unsteady movements while on Gabapentin, which can lead to stumbling or difficulty walking.
  3. Vomiting or diarrhea: Gastrointestinal upset, including vomiting and diarrhea, can occur in some dogs taking Gabapentin.
  4. Excessive drooling or panting: In rare cases, Gabapentin may cause excessive drooling or panting in dogs.

Galliprant Side Effects:

  1. Vomiting or diarrhea: Like Gabapentin, Galliprant can also cause gastrointestinal issues such as vomiting and diarrhea in some dogs.
  2. Loss of appetite: Some dogs on Galliprant may experience a decrease in appetite.
  3. Lethargy: Dogs taking Galliprant might appear more tired or lethargic than usual.
  4. Changes in behavior: In rare instances, Galliprant may cause changes in a dog’s behavior, such as increased aggression or agitation.


1. What is Gabapentin and Galliprant?

Gabapentin is a medication that is commonly used in dogs to relieve neuropathic pain and seizures. It is also prescribed to manage arthritis pain in dogs. Galliprant, on the other hand, is an anti-inflammatory drug that is prescribed to manage pain and inflammation caused by osteoarthritis in dogs.

2. Is it safe for dogs to take Gabapentin and Galliprant together?

According to veterinarians, it is safe for dogs to take Gabapentin and Galliprant together as long as it is prescribed by a veterinary professional and the dog is closely monitored for any adverse reactions or side effects.

3. What are the benefits of taking Gabapentin and Galliprant together?

Taking Gabapentin and Galliprant together can provide pain relief and inflammation control for dogs who are suffering from chronic pain due to osteoarthritis. Gabapentin helps manage neuropathic pain while Galliprant reduces inflammation in dogs.

4. What should I do if my dog is already taking Gabapentin or Galliprant?

If your dog is already taking Gabapentin or Galliprant for pain relief, it is best to consult with a veterinarian before adding or changing any medications to your dog’s regimen.

5. Is Gabapentin prescribed differently than Galliprant?

Yes, Gabapentin is typically prescribed by the veterinarian in milligrams per kilogram of the dog’s body weight. Galliprant, on the other hand, is prescribed in milligrams based on the dog’s body weight. You should always follow the veterinarian’s dosage instructions carefully.

6. What are the side effects of Gabapentin and Galliprant?

The common side effects of Gabapentin in dogs include sedation, stumbling or lack of coordination, and gastrointestinal upset. Galliprant may cause gastrointestinal upset and decreased appetite in dogs.

7. Can Gabapentin and Galliprant be given to dogs with kidney or liver problems?

It is not recommended to give Gabapentin and Galliprant to dogs with kidney or liver problems. The veterinarian will assess the dog’s overall health and history to determine if either medication is safe to use.

In Conclusion

Galliprant and Gabapentin serve different purposes in managing pain and inflammation in dogs. However, it is possible for them to be taken together under the supervision of a veterinarian.

Each dog’s individual health status, medical history, and specific needs will determine the appropriateness of combining these medications.

Always consult with your veterinarian before making any changes to your dog’s medication regimen to ensure safe and effective treatment tailored to their unique needs.

Please take the time and leave a comment below if this article helped you, or you have any additional questions.

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